Welcome to the Martin Zenke Lab, Faculty of Medicine of RWTH Aachen University and RWTH Aachen University Hospital Aachen, Germany. The Martin Zenke Lab is affiliated with the Department of Hematology, Oncology and Stem Cell Transplantation, Department of Medicine IV, RWTH Aachen University Medical School, Aachen, Germany.
The Martin Zenke Lab studies stem cells and their differentiated progeny. This includes adult stem cells, such as hematopoietic and mesenchymal stem cells, and embryonic stem cells (ES cells). We also study engineered stem cells, such as induced pluripotent stem cells (iPS cells), and use precision genome engineering with CRISPR/Cas to generate cells with desired properties. Stem cells are differentiated into a large array of terminally differentiated cell types with a focus on antigen presenting dendritic cells. Additionally, iPS cells are differentiated into mesenchymal cells, endothelial cells, mast cells and megakaryocytes, which are used for disease modelling and compound screening.